Sitting against the base of Fremont's hills, Niles is physically divided from other parts of Fremont and neighboring Union City by Mission Boulevard (State Route 238) to the east and north, Alameda Creek to the south, Union Pacific Railroad to the west and southeast, and the Quarry Lakes to the southwest. The District retains its small town feel anchored by a tight-knit community in the City of Fremont, CA.
The town of Niles was the home of one of the first West Coast motion picture companies, Essanay Studios. Charlie Chaplin and Broncho Billy Anderson filmed some of their most famous silent movies in Niles. Scenic Niles Canyon stretches between Niles and Sunol.